IMMUNOLOGICALLY ACTIVE COMPOUNDS Russian patent published in 2012 - IPC A61K39/00 C07K17/04 A61P37/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes a system of carrier microparticles containing one or more proteins, peptides, nucleic acids, carbohydrates, lipids or other biologically active substances with or without attached target molecules. The invention describes immunomodulatory compounds for induction of an immunomodulatory effect - protective immunity and tolerance. The immunobiologically active compound contains a pathogen-associated molecular structure and a carrier in the form of agarose microparticles. The molecular structure represents at least an immunobiologically active antigen and an antigen epitope with the antigen epitope is a peptide, a protein, a recombinant peptide or a multipeptide, a lipid, a carbohydrate, a nucleic acid or their combinations. There are described methods for identifying the immunobiologically active peptides for preparing the immunobiologically active compounds and methods for inducing a tolerant immune response and enhancing immunity with the use of the compounds described in the invention.

EFFECT: invention provides stable compounds with the wide range of immunogens and target molecules enables stimulating protective immunity and tolerance in both infected, and non-infected hosts.

52 cl, 5 dwg, 4 tbl, 34 ex