FIELD: medicine.
SUBSTANCE: recovered polypeptide complex is involved in epigenetic gene expression control in mammals. The complex contains the protein Blimpl or its homologue PRD1 having site-specific DNA-binding activity, and the protein PRMT5.
EFFECT: complex is able to regulate gene expression in cells, particularly in stem cells in mammals that is ensured by regulated R3 methylation in C-terminal regions of the histones H2A and H4.
12 cl, 8 dwg, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PERSONALISED PRODUCTION OF BIOPREPARATIONS AND STEM CELL REPROGRAMMING METHOD | 2012 |
|
RU2595390C2 |
| METHODS OF DERIVING DIFFERENTIATED CELLS FROM STEM CELLS | 2009 |
|
RU2576003C2 |
| METHOD FOR PRODUCING HIGH-QUALITY INDUCED PLURIPOTENT STEM CELLS (IPSC) | 2016 |
|
RU2721266C1 |
| METHODS AND COMPOSITIONS FOR TREATING TUMORS | 2017 |
|
RU2741786C2 |
| STIMULATION OF PATHWAY Wnt IN REPROGRAMMING SOMATIC CELLS | 2008 |
|
RU2492232C2 |
| METHOD OF PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS OF PATIENTS WITH DOWN SYNDROME | 2012 |
|
RU2492233C1 |
| TREATMENT, DIAGNOSTICS OR PREVENTION OF LEISHMANIASIS CAUSED BY VARIOUS TYPES OF PARASITES, EXCEPT THAT ONE USED TO PRODUCE HISTONES, WITH USING ALL OF FOUR HISTONES H2A, H2B, H3 AND H4, RECOVERED FROM LEISHMANIA INFANTUM WITH USING VECTOR CONTAINING NUCLEOTIDES CODING SPECIFIED HISTONES | 2004 |
|
RU2380710C2 |
| METHOD OF PRODUCING OF PLURIPOTENT STEM CELLS | 2014 |
|
RU2565548C1 |
| METHOD FOR INCREASING RNA EXPRESSION IN CELL | 2018 |
|
RU2784654C2 |
| TRANSIENT CELLULAR REPROGRAMMING TO REVERSE CELL AGING | 2019 |
|
RU2801316C2 |
