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2 707 057

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IPC

A61M5/32(2006-01-01)

A61K38/14(2006-01-01)

A61P15/00(2006-01-01)

G09B23/28(2006-01-01)

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Application

2019118601, 2019-06-14

(24)

Start date

2019-06-14

(22)

Actual filing date

2019-06-14

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Published

2019-11-21

(72)

Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichYurakova Alesya ViktorovnaAntsiferova Oksana EvgenevnaLokteva Tatyana IvanovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPakhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena EvgenevnaGureev Anastasiya VladimirovnaVajn Darya SergeevnaZhuchenko Maksim Andreevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION WITH CARBAMYLATED DARBEPOETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2019 - IPC A61M5/32 A61K38/14 A61P15/00 G09B23/28

Abstract RU 2707057 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology. Pre-eclampsia model is reproduced in Wistar rats daily from 14 to 20 of pregnancy by intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. To correct simulated endothelial dysfunction, carbamylated darbepoetin 300 mcg/kg is injected subcutaneously once day on 7th, 10th, 13th, 16th and 19th day of pregnancy.

EFFECT: method enables correcting endothelial dysfunction in a simulated pathology in pregnant rats by pronounced antiischemic and antioxidant actions of carbamylated darbepoetin.

1 cl, 1 tbl, 1 ex

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RU 2 707 057 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Yurakova Alesya Viktorovna

Antsiferova Oksana Evgenevna

Lokteva Tatyana Ivanovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureev Anastasiya Vladimirovna

Vajn Darya Sergeevna

Zhuchenko Maksim Andreevich

Dates

2019-11-21—Published

2019-06-14—Filed