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IPC

A61M5/32(2006-01-01)

A61K38/14(2006-01-01)

A61P15/00(2006-01-01)

G09B23/28(2006-01-01)

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Application

2019132872, 2019-10-16

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Start date

2019-10-16

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Actual filing date

2019-10-16

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Published

2020-04-24

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Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichYurakova Alesya ViktorovnaAntsiferova Oksana EvgenevnaLokteva Tatyana IvanovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPakhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena EvgenevnaGureeva Anastasiya VladimirovnaVajn Darya SergeevnaZhuchenko Maksim Andreevich

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Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF CORRECTION OF MICROCIRCULATION DISORDERS IN PLACENTA WITH CARBAMYLATED DARBEPOETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC A61M5/32 A61K38/14 A61P15/00 G09B23/28

Abstract RU 2720103 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of microcirculation disorders in placenta with carbamylated darbepoetin in ADMA-like model of preeclampsia. That is ensured by reproducing a model of preeclampsia in Wistar rats by daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg from 14th to 20th day of pregnancy. To correct the simulated pathology, carbamylated darbepoetin is administered subcutaneously in dose of 300 mcg/kg once day on 7th, 10th, 13th, 16th and 19th day of pregnancy.

EFFECT: method provides pronounced correction of microcirculation in placenta due to reduction of oxidative stress, stabilization of hemodynamics caused by antioxidant and antiischemic effects of administered preparation.

1 cl, 1 tbl, 1 ex

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RU 2 720 103 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Yurakova Alesya Viktorovna

Antsiferova Oksana Evgenevna

Lokteva Tatyana Ivanovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Zhuchenko Maksim Andreevich

Dates

2020-04-24—Published

2019-10-16—Filed