METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION BY A PEPTIDE IMITATING ALPHA-HELIX B ERYTHROPOIETIN, WITH AN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC G09B23/28 A61K38/14 A61P15/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of endothelial dysfunction in pregnant women. A method of correcting endothelial dysfunction in an ADMA-like pre-eclampsia model involves reproducing a pre-eclampsia model in Wistar rats daily from 14th to 20th day of pregnancy by intraperitoneal administration of L-nitro-arginine-methyl ester 25 mg/kg, correction of simulated pathology by intraperitoneal introduction of a peptide imitating α-helix B of erythropoietin (P-αB) in dose of 50 mcg/kg/day from 10th to 20th day of pregnancy.

EFFECT: method results in pronounced endothelial dysfunction correction in simulated pathology.

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