FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, can be used for correction of endothelial dysfunction in ADMA-like model of preeclampsia. That is ensured by reproducing the pre-eclampsia model in Wistar rats by daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg on 14–20th day of pregnancy. Correction of simulated pathology is carried out by subcutaneous administration of asialised erythropoietin from 10 to 20 days of pregnancy in dose of 2.4 mcg/kg once a day.
EFFECT: method provides pronounced correction of endothelial dysfunction in the simulated pathology due to pronounced anti-ischemic and antioxidant action of the administered preparation.
1 cl, 1 tbl, 1 ex
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