FIELD: medicine.
SUBSTANCE: what is described is a new pharmaceutically solid preparation of a vasopressin antagonist which contains: (a) 7-chlor-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro- 1H-benzoazepine and/or its salt; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in the amount of 50% or more; and (c) at least one of the ingredients specified in a group consisting of carmellose, sodium carboxymethyl starch, crospovidone and hydroxypropylcellulose with a lower degree of substitution with an average diameter of particles 30 to 70 mcm and 90% of the cumulative diameter of 100 to 200 mcm.
EFFECT: pharmaceutical solid preparation shows excellent desintegration properties and solubility leading to adequate gastrointestinal absorbability of the active ingredients.
17 cl, 4 tbl, 21 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DISINTEGRATING AGENT | 1999 |
|
RU2201215C2 |
| SOLID DISPERSION OF TOLVAPTAN AND METHOD FOR PRODUCING IT | 2011 |
|
RU2579745C2 |
| TABLET, WHICH IS DECOMPOSED IN MOUTH | 2008 |
|
RU2478375C2 |
| ESCITALOPRAM AND HARD PHARMACETICAL COMPOSITION CONTAINING IT | 2007 |
|
RU2463039C2 |
| COMPOSITION OF SOLID QUICK-DISINTEGRATING TABLET | 2008 |
|
RU2472493C2 |
| PHARMACEUTICAL COMPOSITION | 2008 |
|
RU2470637C2 |
| PILL CONTAINING METHANESULFONATE HYDRATE OF 1-CYCLOPROPYL-8-(DIFLUOROMETHOXY)-7-[(1R)-1-METHYL-2,3-DIHYDRO-1H-ISOINDOLE-5-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID | 2012 |
|
RU2633477C2 |
| COMPOSITIONS | 2015 |
|
RU2717574C2 |
| SOLID PHARMACEUTICAL PREPARATION OF MATRIX TYPE | 2012 |
|
RU2600797C2 |
| DOUBLE-ACTION PHARMACEUTICAL COMPOSITIONS OF SUBMOLECULAR STRUCTURE OF ANGIOTENSIN RECEPTOR BLOCKER (ARB) AND NEUTRAL ENDOPEPTIDASE (NEP) INHIBITOR | 2008 |
|
RU2493844C2 |
