FIELD: medicine.
SUBSTANCE: invention relates to system of peroral delivery of medications with controlled release into intestine region, which includes therapeutically active component, selected from sodium diclofenac, oxprenolol, methoprolol, nifedipine, indomethacin, ibuprofen, isosorbide, theophylline and pharmaceutically acceptable carrier. As pharmaceutically acceptable carrier the system contains polymer carrier based on interpolyelectrolyte complex, obtained by interaction of cross-linked polyacrylic acid (polyanion) with dimethylaminoethyl methacrylate copolymer and neutral esters of methacrylic acid (polycation).
EFFECT: invention ensures controlled release along entire intestine, dose reduction and prolonged action of active component.
4 cl, 4 dwg, 3 tbl, 5 ex
Authors
Dates
2012-11-27—Published
2011-05-10—Filed