FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology, genetic engineering and virology. Described is a chimeric protein comprising an L2-epitope of a human papillomavirus (HPV) type-16 inserted in a loop region of a human papillomavirus type-16 L1 protein; and a capsid which is an aggregate of the chimeric protein. The loop region to which the L2-epitope is to be inserted is located between an amino acid residue at position 430 and an amino acid residue at position 433. The L2-epitope has an amino acid sequence represented by any one of the following formulae: LYKTCKQAGTCPPDIIPKVEG (18-38 L2-epitope); GGLGIGTGSGTGGRTGYIPL (56-75 L2-epitope); and DPVGPLDPSIVSLVEESSFI (96-115 L2-epitope).
EFFECT: invention can be used to obtain a vaccine against human papillomavirus.
18 cl, 7 dwg, 5 tbl, 3 ex
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