DRUG PREPARATION WITH CARDIOPROTECTIVE ACTIVITY Russian patent published in 2013 - IPC A61K31/5375 A61K31/4174 A61P9/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: what is presented is the use of the drug -2-(2-morpholinoethyl)thio-5-ethoxybenzimidazole dihydrochloride (the anxiolytic Afobazole) as a preparation with cardioprotective activity. It is shown that Afobazole (5-10 mg/kg intravenously or intraperitoneally) on various models of myocardial ischemia and heart rhythm disorder exhibits manifested cardioprotective activity observed primarily at the myocardium and may be related to a certain extent to its affinity for sigma1-receptors localised in cardiac myocytes. Antiarrhythmic action of Afobazole is preferentially conditioned by its ability to increase electrical stability of the maycardium directly.

EFFECT: findings entitle recommending the anxiolytic Afobazole to be used in clinical practice as a cardioprotector for the purpose of preventing and treating cardiovascular disorders in the patients suffering cardiophobic and/or asthenic-depressive syndromes burdened by cardiopathies.

1 dwg, 3 tbl, 3 ex