METHOD OF DIFFERENTIAL DIAGNOSTICS OF BENIGN, PRECANCEROUS AND MALIGNANT CERVICAL NEOPLASMS Russian patent published in 2013 - IPC A61B1/02 A61B1/07 A61B1/303 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, gynecology, oncology. High-speed optical coherence tomography (HOCT) is performed by means of probe under control of colposcopy at video frame rate, with the study of kinematic functional characteristics of cervical tissue: intensity of reverse signal dispersion, rate of signal extinction, change of value and number of subepithelial formations, characterising uniformity and variability of tissue vascularisation and vessel elasticity, mobility of whole image, motion of subepithelial formations. Examination is performed at central wavelength 1280 nm, power on object 0.75 mW, resolution 15-30 mcm, scanning depth 2 mm, by smooth movement of OCT-device probe on entire surface of cervix from cervical canal to periphery on 12 vectors of 12-h conventional clock face. If image with constant change of value and number of subepithelial rounded formations of small diameter with low capability of reverse dispersion, straight horizontal basal boundary of bottom layer of whole image is obtained, healthy cervical tissues are diagnosed, in case of presence of mobile subepithelial structures of large size with low capability of reverse dispersion, constant change of their shapes, low rate of signal extinction, indefinite shape of basal bottom boundary of lower layer, diagnosed is viral cervicitis, in case of absence of structural changes and presence of fluctuating movements of whole hOCT-image and broken basal boundary, precancer is diagnosed, if in zone of interest structural and dynamic changes and fluctuations of entire volume of whole hOCT-image are, malignant neoplasm is diagnosed.

EFFECT: method makes it possible to increase accuracy of diagnostics, reduce examination time and trauma of manipulations.

2 cl, 3 ex