METHOD FOR USING IMMUNOLOGICAL MARKERS FOR PREDICTION OF PROLIFERATIONS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS ASSOCIATED WITH PAPILLOMAVIRUS INFECTION Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: method for prediction of the proliferation of cervical intraepithelial neoplasias (CIN) associated with papillomavirus infection consisting in measuring a patient's blood and cervical immunological values, involves using a coefficient P, and if the coefficient P is more than 0.5, the patient is referred to a risk group of the proliferation of the disease; the coefficient P is 0.5 or less shows no risk of the proliferation of the disease. The coefficient P is calculated by means of a mathematical model: $$P=\left(\frac{1}{1+e^{-\text{logotype}(P)}}\right),$$ where logotype(P) = constant+a₁X₁+a₂X₂+…+a_nX_n , wherein P is a probability of referring the patient to the risk group, a_i is regression coefficients, X_i are values included in the model.

EFFECT: improved diagnostic accuracy.

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