HETEROLOGOUS PEPTIDE MINI-ANTIGENE IN POLYMER PARTICLE FOR MAKING ANTI-ALLERGY VACCINE Russian patent published in 2013 - IPC C07K14/00 A61K38/02 A61P37/08 

FIELD: chemistry.

SUBSTANCE: invention discloses artificial peptide mini-antigens (PMA) which can be used to induce controlled protective humoral IgG-mediated immune response against allergen. The mini-antigen includes: hydrophobic peptides from different proteins and any pathogens which are linked with pockets of the most common MHC (major histocompatibility complex) molecules class II and to which, in the human population, there are memory T cells (memory T cell T epitopes (MTC)), and hydrophilic peptides from different proteins which are on the surface of wild type allergen, which are conjugated onto the support of the cladding of the polymer particle and are accessible for antibodies. (The structure of the mini-antigen is shown on fig 14 in the description). The mini-antigens are characterised by the capacity to replace B epitopes with peptides of another allergen while preserving the nucleus of the MTC T epitopes, which enables to use the peptide mini-antigens to make anti-allergy vaccines against different types of allergies. The presence of memory T cells helps to considerably speed up immune response triggering. The introduction of peptides of only basic allergen proteins into the structure ensures anti-allergy protection with minimal load on the immune system.

EFFECT: absence of binding of IgE with peptides makes vaccination safe and fast.

14 dwg, 2 tbl, 3 ex