PREDICTING RISK OF ISCHEMIC STROKE IN PATIENTS WITH ISCHEMIC HEART DISEASE AND PERSISTENT ATRIAL FIBRILLATION Russian patent published in 2013 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine and can be used for predicting risk of ischemic stroke development in patients with ischemic heart disease and persistent form of atrial fibrillation. The following parameters are analysed in patients: time of beginning of adenosine diphosphate-induced platelet aggregation in seconds, concentration of thrombin-activated fibrinolysis inhibitor in percent, maximal rate of blood expulsion from left atrial auricle in centimeters per second, concentration of soluble fibrin-monomer complexes in milligram-percent, fraction of left atrial output in percent, as well as presence of absence of thrombosis of left atrial auricle, index S is calculated by formula: S=2.58+0.06×A+0.003×B-0.01×C-0.017×D-0.08×E+0.17F; where A is concentration of soluble fibrin-monomer complexes in milligram-percent; B is concentration of thrombin-activated fibrinolysis inhibitor in percent; C is maximal rate of blood expulsion from left atrial auricle in centimeters per second; D is fraction of left atrial output in percent; E is beginning of adenosine diphosphate-induced platelet aggregation in seconds; F is presence of absence of thrombosis of left atrial auricle: 0 - absence, 1 - presence; if S index is lower or equals 0.5, low risk of ischemic stroke development is predicted, if S index is higher than 0.5 but lower than 1.5, middle risk of ischemic stroke development is predicted; if S index is higher or equals 1.5, high risk of ischemic stroke development is predicted.

EFFECT: method makes it possible to predict risk of ischemic stroke development in patients with ischemic heart disease and persistent form of atrial fibrillation.

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