PHARMACEUTICAL COMPOSITION AND METHOD OF THERAPY OF NEURODEGENERATIVE DISORDERS, INCLUDING AMYOTROPHIC LATERAL SCLEROSIS Russian patent published in 2013 - IPC A61K48/00 A61P25/28 B82B1/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine, and concerns a pharmaceutical composition for the therapy of neurodegenerative disorders, particularly amyotrophic lateral sclerosis, containing an effective amount of an adenoviral vector in the form of a non-replicating nanoparticle of a human adenovirus serotype 5 genome with an insert of human angiogenin gene producing angiogenin and the non-replicating nanoparticles of the human adenovirus serotype 5 genome with an insert of a vascular endothelial growth factor gene producing the vascular endothelial growth factor in the human body, wherein the human angiogenin gene and the human vascular endothelial growth factor gene are cloned in two expression cassettes of one non-replicating nanoparticles of the human adenovirus serotype 5 genome, a method of treating amyotrophic lateral sclerosis implying administering a therapeutically effective dose of the above pharmaceutical composition.

EFFECT: group of inventions provides the higher therapeutic effectiveness and the absence of undesired side effects in the patients.

19 cl, 7 ex, 4 dwg, 2 tbl