OSTEOCRIN, LEBETIN OR ATRIAL NATRIURETIC PEPTIDE (ANP) FOR DESTRUCTION OF BACTERIAL BIOFILMS Russian patent published in 2024 - IPC A61K38/22 A61K38/17 A61K45/06 A61P11/00 A61P31/04 

FIELD: biotechnology.

SUBSTANCE: disclosed is the use of a natriuretic peptide selected from the group consisting of osteocrin, lebetin and ANP peptide for the therapeutic treatment of a bacterial infection associated with the presence of a bacterial biofilm in a subject, wherein said natriuretic peptide destroys said bacterial biofilm, wherein said bacterial infection is an infection caused by a bacterium of the genus Pseudomonas. Also disclosed is: a pharmaceutical composition for the therapeutic treatment of a bacterial infection, the use of a pharmaceutical antibacterial combination comprising a natriuretic peptide, selected from the group consisting of osteocrin, lebetin and ANP peptide, and an antibiotic and the in vitro or ex vivo use of a natriuretic peptide selected from the group consisting of osteocrin, lebetin and ANP peptide for dispersing the bacterial biofilm, wherein said bacterial biofilm contains at least one bacterium of the genus Pseudomonas.

EFFECT: invention can be used to treat a bacterial infection associated with the presence of a bacterial biofilm in a subject, where the natriuretic peptide destroys the bacterial biofilm, and where said bacterial infection is an infection caused by a bacterium of the genus Pseudomonas.

10 cl, 1 dwg, 8 tbl, 11 ex