METHOD FOR PREPARING ANTIPERSPIRANT ACTIVE COMPOUND HAVING SEC CHROMATOGRAM SHOWING HIGH SEC PEAK 4 INTENSITY Russian patent published in 2013 - IPC A61K8/18 A61K8/26 A61K8/28 A61Q15/00 

FIELD: medicine.

SUBSTANCE: invention refers to a new method for preparing an antiperspirant active compound having SEC chromatogram showing high SEC peak 4 intensity. The method involves heating an aqueous solution containing an aluminium salt having a molar ratio of aluminium to chlorine of 0.3:1 to 3:1, optionally with a buffer substance at temperature 50°C to 100°C in a backflow condenser tank for 1 hour to 6 hours to prepare an aluminium salt solution, adding an aqueous solution of sodium hydroxide for preparing the aluminium salt solution having the molar ratio of OH:Al 2:1 to 2.6:1 so that to prepare the aluminium salt solution with adjusted pH, having pH 2 to 5, providing calcium ions and adding optionally an aqueous solution containing zirconium to the aluminium salt solution with adjusted pH so that to prepare the aluminium and zirconium salt solution having the molar ratio of aluminium and zirconium 5:1 to 10:1. When the calcium base is used, the weight ratio of sodium hydroxide to the calcium base falls within the range of more than 0 to 20, or when a calcium ion source represents a salt, then the weight ratio of sodium hydroxide to the calcium ions falls within the range of more than 0 to 11.

EFFECT: method enables simplifying the stage of purification of the prepared antiperspirant product.

22 cl, 5 ex