BENZOCYCLOHEPTANE AND BENZOXEPINE DERIVATIVES Russian patent published in 2013 - IPC C07C215/44 C07D313/08 C07D405/04 C07D207/09 C07D211/14 C07D241/04 C07D265/30 C07D239/24 C07D213/02 C07D215/02 C07D317/48 A61K31/335 A61P1/00 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of formula (I), including any stereochemical isomer forms thereof, or a pharmaceutically acceptable salt thereof, , wherein A is phenyl or 6-member aromatic heterocycle containing 1 or 2 nitrogen atom; wherein said phenyl or 6-member aromatic heterocycle may be optionally condensed with phenyl; Z is CH₂ or O; R¹ is halogen, hydroxyl, C_1-4alkyl, C_1-4alkyloxy, or provided A is phenyl, then two neighbour substitutes R¹ may be taken together to produce a radical of formula: -O-CH₂-O- (a-1) or -O-CH₂-CH₂-O- (a-2); R² is hydrogen or C_1-4alkyl; each R³ and R⁴ independently is hydrogen, C_1-6alkyl, C_1-4alklyloxyC_1-6alkyl or phenylC_1-4alkyl; or R³ and R⁴ taken together with a nitrogen atom whereto attached form a radical of formula or , wherein X₁ is CH₂ or CHOH; and X₂ is CH₂, O or NR⁶; R⁵ is hydrogen, halogen, C_1-4alkyl or C_1-4alkyloxy; R⁶ is hydrogen, C_1-4alkyl, C_1-4alkylcarbonyl; n is equal to an integer 0, 1 or 2; provided the compound is other than , or a pharmaceutically acceptable salt thereof.

EFFECT: compounds are used to treat the diseases the treatment of which is affected, mediated or promoted by GHSlA-r receptor activation The present invention also refers to pharmaceutical compositions and an intermediate compound of formula II: .

22 cl, 10 tbl, 11 ex