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2 496 878

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IPC

C12N15/11(2006-01-01)

B82B3/00(2006-01-01)

C12N7/04(2006-01-01)

(21) (22)

Application

2012118712/10, 2012-05-04

(24)

Start date

2012-05-04

(22)

Actual filing date

2012-05-04

(45)

Published

2013-10-27

(72)

Inventor

Zarytova Valentina FilippovnaIsmagilov Zinfer RishatovichLevina Asja SaulovnaRepkova Marina NikolaevnaShikina Nadezhda Vasil'EvnaZagrebel'Nyj Stanislav NikolaevichMazurkova Natal'Ja Alekseevna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Kataliza Im. G.K. Boreskova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Federal'Noe Bjudzhetnoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Gnts VbFederal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Natsional'Nyj Issledovatel'Skij Gosudarstvennyj Universitet"

NANOCOMPOSITE WITH ACTIVE LIGAND, METHOD OF ITS PREPARATION AND METHOD OF ADDRESS INACTIVATION OF FLU VIRUS INSIDE CELL Russian patent published in 2013 - IPC C12N15/11 B82B3/00 C12N7/04

Abstract RU 2496878 C1

FIELD: biotechnologies.

SUBSTANCE: nanocomposites made of nanoparticles of titanium dioxide in amorphous or crystalline (anatase, brookite) form, immobilised polylysine derivatives of oligonucleotides (PL-oligo) and photoactivated arylazide groups introduced in amino groups of polylysine. All components of the nanocomposite perform a certain function: TiO₂-nanoparticles support transfection of cells; polylysine helps to immobilise oligonucleotide onto the surface of nanoparticles and adds functional groups (NH₂), which make it possible to add additional reaction-capable groups; oligonucleotides of certain sequence forward the composite towards the target sections of the virus RNA; the photoactivated perfluoroarylazide group after irradiation with light may damage nucleic acids.

EFFECT: directed action at genetic material inside a cell and suppression of its further functioning.

9 cl, 3 dwg, 15 ex

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RU 2 496 878 C1

Authors

Zarytova Valentina Filippovna

Ismagilov Zinfer Rishatovich

Levina Asja Saulovna

Repkova Marina Nikolaevna

Shikina Nadezhda Vasil'Evna

Zagrebel'Nyj Stanislav Nikolaevich

Mazurkova Natal'Ja Alekseevna

Dates

2013-10-27—Published

2012-05-04—Filed