METHOD OF DETECTING DISORDERS OF PHYSIOLOGICAL IMMUNOSUPPRESSION IN CHILDREN IN FIRST GENERATION THROUGH PARENTAL LINEAGE WITH HEREDITARY TAINTED IN CONDITIONS OF ALUMINUM EXCESSIVE EXPOSURE Russian patent published in 2018 - IPC G01N33/68 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, in particular to molecular genetic diagnosis, and discloses a method for detecting disorder of physiological immunosuppression in children in the first generation through parental lineage with hereditary tainted in conditions of aluminum excessive exposure. Method is characterized in that a combination of the following diagnostic criteria is used: the genetic criterion of the FOXp3 gene, level of T-regulatory lymphocytes CD127 and the level of contamination with aluminum above the reference one. At simultaneous presence of variant homozygous or heterozygous genotypes of the gene FOXp3 T(-3499) C from the son and/or from the mother, decrease in relative and absolute level of T-regulatory lymphocytes in child blood, on the membrane of lymphocytes there is no receptor CD127 (CD127^-), with respect to the lower limit of the physiological norm and when the concentration of aluminum in the blood exceeds the reference level, make a conclusion about the presence of disorder of physiological immunosuppression in child in the first generation through parental lineage with hereditary tainted in conditions of aluminum excessive exposure.

EFFECT: invention can be used to identify the negative impact of aluminum coming from the environment.

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