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2 504 326

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IPC

A61B5/00(2006-01-01)

G01N33/48(2006-01-01)

(21) (22)

Application

2012154065/14, 2012-12-13

(24)

Start date

2012-12-13

(22)

Actual filing date

2012-12-13

(45)

Published

2014-01-20

(72)

Inventor

Baturina Irina LeonidovnaOrner Irina Jur'EvnaAbramovskikh Ol'Ga SergeevnaZotova Marija AleksandrovnaTelesheva Larisa FedorovnaZharov Aleksandr Vladimirovich

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Meditsinskaja Akademija" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Vpo Chelgma Minzdravsotsrazvitija Rossii)

METHOD OF PREDICTING UNFAVOURABLE COURSE OF LOCALLY SPREAD FORMS OF HUMAN PAPILLOMA VIRUS-ASSOCIATED CERVICAL CANCER Russian patent published in 2014 - IPC A61B5/00 G01N33/48

Abstract RU 2504326 C1

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncogynecology. Immunological parameters are determined: absolute number of lymphocytes (lim_ab), TNFα (TNFα-k) and IL-10 (IL-IL10_k) in peripheral blood, as well as TNFα (TNFα-c) and IL-4 (IL-4_c) in cervical mucus. On the basis of obtained data parameter F(x) is calculated by formula: F(x): P(x)=9.265+1,749x(lim_ab)+0.013×(IL-4_c)+0.005×(IL-10_k)-0.410×(TNFα-k)-0.206×(TNPα-c). If value F(x) is higher than 0.555, unfavourable course of tumour process is predicted, in case if it is lower than 0.555, favourable course is predicted.

EFFECT: method makes it possible to increase prognosis reliability due to taking into account immunological parameters of both blood and cervical secretion.

3 tbl, 2 ex

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RU 2 504 326 C1

Authors

Baturina Irina Leonidovna

Orner Irina Jur'Evna

Abramovskikh Ol'Ga Sergeevna

Zotova Marija Aleksandrovna

Telesheva Larisa Fedorovna

Zharov Aleksandr Vladimirovich

Dates

2014-01-20—Published

2012-12-13—Filed