PRODRUGS OF NONSTEROID ANTI-INFLAMMATORY AGENTS (NSAIA) WITH VERY HIGH SPEED OF PENETRATION THROUGH SKIN AND MEMBRANES, AND NEW MEDICAL APPLICATIONS OF ABOVE SAID PRODRUGS Russian patent published in 2014 - IPC C07D209/32 C07D231/12 C07D213/74 C07D215/10 C07D217/12 C07D471/08 C07D487/08 A61K31/44 A61P29/00 

Abstract RU 2509076 C2

FIELD: biotechnologies.

SUBSTANCE: invention refers to new positively charged NSAIA prodrugs of a common formula (1, 2a, 2b, 2c or 2d) of "1, 2a, 2b, 2c or 2d structure"

Structure 1, Structure 2a,

Structure 2b, Structure 2c, Structure 2d. Values of R, R1, R2, R3, R4, R5, Ary, X radicals are presented in Claims 1,2.

EFFECT: increasing agent penetration speed.

22 cl, 14 tbl

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RU 2 509 076 C2

Authors

Juj Chunsi

Sjuj Lina

Dates

2014-03-10Published

2007-06-04Filed