METHOD AND INTERMEDIATE COMPOUNDS FOR OBTAINING DERIVATIVES OF 5-BIPHENYL-4-YL-2-METHYLPENTANIC ACID Russian patent published in 2014 - IPC C07D207/263 C07D207/38 C07C271/22 A61K31/4015 

Abstract RU 2513521 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel intermediate compounds of structural formulas 2, 4, 5, 6, 7, 9, 10, 11, 12, 16, given in the invention formula. Said compounds are used for obtaining NEP-inhibitor, which represents N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanic acid or its pharmaceutically acceptable salt, or its pro-drug, representing ethyl ether of N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanic acid or its salt.

EFFECT: obtaining novel compounds.

12 cl, 6 dwg, 77 ex, 4 tbl

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Authors

Dejvid Khuk

Bernkhard Riss

Daniel' Kaufmann

Mattias Napp

Ehrkhard Bappert

Filipp Polle

Dzhonatan Medlok

Antonio Tsanotti-Gerosa

Dates

2014-04-20Published

2009-01-16Filed