FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine and concerns methods of treating growth hormone or insulin-like growth factor 1 deficiency in a patient involving administering an immunogenic amount of a vaccine containing a chimeric somatostatin-14 based polypeptide bound to inactivated chloramphenicol acetyltransferase (CAT), and an adjuvant; the vaccine for treating the patient having growth hormone or insulin-like growth factor 1 deficiency; a method of treating obesity in the patient involving administering the immunogenic amount of the vaccine.
EFFECT: group of inventions provide the immunogenicity for somatostatin and higher release of endogenously produced growth hormone and/or insulin-like growth factor 1.
22 cl, 8 ex, 6 dwg, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CHLORAMPHENICOL ACETYL TRANSFERASE (CAT) DEFECTIVE SOMATOSTATIN FUSED PROTEIN AND USING IT | 2008 |
|
RU2501565C2 |
| RECOMBINANT PROTEIN GBD-SSTAD-SSTAD, A METHOD FOR PRODUCTION AND USE THEREOF | 2019 |
|
RU2722849C1 |
| CHIMERIC FIBROBLAST GROWTH FACTORS WITH CHANGED RECEPTOR SPECIFICITY | 2010 |
|
RU2573896C2 |
| RECOMBINANT PROTEINS AND THEIR APPLICATIONS IN THERAPEUTIC PURPOSES | 2018 |
|
RU2766595C2 |
| RECOMBINANT PROTEINS AND THEIR THERAPEUTIC USES | 2012 |
|
RU2650574C2 |
| BINDING PROTEINS SPECIFIC TO INSULIN-LIKE GROWTH FACTORS, AND USING THEM | 2013 |
|
RU2549703C2 |
| SELF-ASSEMBLY SYNTHETIC PROTEINS | 2014 |
|
RU2801230C2 |
| SELF-ASSEMBLING SYNTHETIC PROTEINS | 2014 |
|
RU2747857C2 |
| FUSED GROWTH HORMONE PROTEINS | 2008 |
|
RU2473554C2 |
| ANTI-CANCER VACCINES TARGETING PRAME AND THEIR APPLICATIONS | 2018 |
|
RU2748903C1 |
