FIELD: biotech.
SUBSTANCE: invention relates to the field of biotechnology. The present invention discloses nucleic acid molecules containing one or more nucleic acid sequences that encode a mutated PRAME consensus antigen. Disclosed are vectors, compositions and vaccines containing one or more nucleic acid sequences that encode a mutated PRAME consensus antigen. Methods of treating a subject with a PRAME-expressing tumor and methods of preventing a PRAME-expressing tumor are disclosed. A mutated PRAME consensus antigen is disclosed.
EFFECT: methods of treating a PRAME-expressing tumor disclosed.
41 cl, 19 dwg, 7 tbl
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