MEDICAL DEVICES AND METHODS COMPRISING POLYMERS CONTAINING BIOLOGICALLY ACTIVE SUBSTANCES Russian patent published in 2014 - IPC A61L27/14 A61K31/4168 A61F2/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: implant represents a medicated polymer device, e.g. in the form of a rod, designed for release control of a biologically active substance clonidine and derivatives thereof, such as clonidine HCl, for a long period of time, e.g. for 2 months, 3 months, 4 months and even 4.5 months. The above polymer preferentially represents a biodegradable polymer, such as poly(lactide-co-glycolide) or poly(lactic acid). A challenge of using medicated salt forms HCl, such as clonidine consists in release control of the high water-soluble medication up to 4.5 months. It has been found that a particle size distribution control in the medicated powder can provide more uniform medication distribution in a polymer carrier which can be regulated. This enables avoiding formation of aggregates causing faster medication release.

EFFECT: invention refers to medical devices able to release the biologically active substances.

5 cl, 10 dwg, 8 ex