FIELD: medicine.
SUBSTANCE: invention refers to a method for prediction of increasing a cardio-malleolar-vascular stiffness index in the patients with chronic obstructive pulmonary disease combined with ischemic heart disease which involves studying initial systemic inflammatory biomarkers of C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha) and anti-inflammatory interleukine 4 (IL-4) and calculating the discriminant equation D=1.42*(TNF-α)+0.78*(CRP)-0.534*(IL-4), and if D is more than 4.82, a one-year increase of the cardio-malleolar-vascular stiffness index for one year is predicted, and if D is 4.82 or less, no increase of the cardio-malleolar-vascular stiffness index is predicted.
EFFECT: more effective prediction of increasing the cardio-malleolar-vascular stiffness index.
2 ex
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