COMPOUNDS WHICH ARE ERK INHIBITORS Russian patent published in 2014 - IPC C07D403/14 C07D401/14 C07D409/14 C07D417/14 A61K31/416 A61K31/4196 A61K31/426 A61K31/435 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula 1.0:

,

where Q represents tetrahydropyridinyl ring substituted. R⁵, R¹ are selected from: (1) pyridyl, substituted with substituent, selected from group, consisting of: -O-CH₃, -O-C₂H₅, -O-CH(CH₃)₂, and -O-(CH₂)₂-O-CH₃, R² is selected from group, consisting of: -OCH₃ and -SCH₃; and R⁵ is selected from (a) substituted triazolylphenyl-, where triazolyl is substituted with one or two alkyl groups, selected from group, consisting of: -C₁-C₄alkyl, (b) substituted triazolylpheenyl-, wheretriazolyl is substituted on nitrogen atom with -C₁-C₄alkyl, (c) substituted triazolylphenyl-, where triazolyl is substituted on nitrogen atom with -C₂alkylene-O-C₁-C₂alkyl, (d) substituted triazolylphenyl-, where triazolyl is substituted on nitrogen atom with -C₂-C₄alkylene-O-CH₃, and (e) substituted triazolylphenyl-, where triazolyl is substituted on nitrogen atom with hydroxy-substituted -C₁-C₄alkyl, and where phenyl is optionally substituted with from 1 to 3 substituents, independently selected from group, consisting of halogen; and their pharmaceutically acceptable salts and solvates, which are claimed as ERK inhibitors.

EFFECT: obtaining pharmaceutically acceptable salts and solvates, claimed as ERK inhibitors.

15 cl, 2 tbl, 32 ex