BONE FILLER MATERIAL Russian patent published in 2014 - IPC A61L27/12 A61L27/32 A61L27/42 A61L31/02 A61L31/08 A61L31/12 B82B1/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a two-phase bone filler material of calcium phosphate / hydroxyapatite (CAP/HAP) containing a sintered CAP nucleus and at least one uniform and closed epitaxial growing layer of nanocrystalline HAP coating the sintered CAP nucleus from above; the epitaxial growing nanocrystals have a size and a morphology identical to a human bone mineral, i.e. the length of 30 to 46 nm and the width of 14 to 22 nm. What is described is a method for preparing the bone filler material of CAP/HAP involving the stages as follows: a) making the sintered CAP nucleus, b) immersing the sintered CAP nucleus into an aqueous solution at 10°C to 50°C to initiate the process of CAP to HAP transformation to form the uniform and closed epitaxial growing nanocrystalline hydroxyapatite on the surface of the sintered CAP nucleus with the epitaxial growing nanocrystals have the size and morphology identical to the human bone mineral, c) terminating the transformation by separating the solid material from the aqueous solution in the presence of the uniform and closed coating of at least one HAP nanocrystalline layer, until the comprehensive completion of the transfomraiton process, d) optionally sterilising the material separated at the stage c), and using the above bone filler material as an implant or a prosthesis for osteogenesis, bone regeneration, bone repair and/or replantation at the site of injury in a human or animal.

EFFECT: preparing method for preparing bone filler material of CAP/HAP.

15 cl, 3 tbl, 6 ex