METHOD FOR PREDICTION OF TERMINATION OF PREGNANCY IN FIRST TRIMESTER Russian patent published in 2014 - IPC G01N33/68 G01N33/76 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to laboratory diagnostics, and concerns predicting the termination of pregnancy in the first trimester. Substance of the method: early (up to 13 weeks) blood serum β-subunit of human chorionic gonadotropin (β-HCG) and soluble vascular endothelial growth factor (sVEGFR-1) a combination of which possesses a high predictive significance to evaluate a risk of early reproductive loss. A discriminant analysis is used to calculate a prognostic index (PI) by formula: PI=0.02949X₁+1.26055X₂-0.91007, wherein X₁ is a β-HCG concentration, ng/ml; X₂ is a sVEGFR-1 concentration, pg/ml; 0.91007 is a constant. If PI<0, the termination of existing pregnancy is predicted in the first trimester, and if PI>0, a low risk of early foetus loss is predicted. A sensitivity of the presented method makes 96.88%, a specificity is 75.0%, and the efficacy of the method is 85.94%.

EFFECT: presented method is minimally invasive, enables early detection of a risk group of the termination of pregnancy which enables conducting the preventing measures aiming at the prevention of habitual miscarriage.

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