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2 469 096

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(51)

IPC

C12Q1/68(2006-01-01)

A61P9/10(2006-01-01)

G01N37/00(2006-01-01)

(21) (22)

Application

2011107170/10, 2011-02-28

(24)

Start date

2011-02-28

(22)

Actual filing date

2011-02-28

(45)

Published

2012-12-10

(72)

Inventor

Andreenko Elena Jur'EvnaBalatskij Aleksandr VladimirovichBojtsov Sergej Anatol'EvichSamokhodskaja Larisa MikhajlovnaTkachuk Vsevolod Arsen'Evich

(73)

Holder

Gosudarstvennoe Uchebno-Nauchnoe Uchrezhdenie Fakul'Tet Fundamental'Noj Meditsiny Moskovskogo Gosudarstvennogo Universiteta Imeni M.V. LomonosovaFederal'Noe Gosudarstvennoe Uchrezhdenie Kardiologicheskij Nauchno-Proizvodstvennyj Kompleks" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR DETECTION OF GENETIC PREDISPOSITION TO DEVELOPING MYOCARIAL INFARCTION IN INDIVIDUALS WITH NO CLINICAL IMPLICATIONS OF ISCHEMIC HEART DISEASE Russian patent published in 2012 - IPC C12Q1/68 A61P9/10 G01N37/00

Abstract RU 2469096 C2

FIELD: medicine.

SUBSTANCE: invention refers to a method for detection of genetic predisposition in an individual with no clinical implications of ischemic heart disease (IHD) to developing myocardial infarction (MI). The invention may be used in cardiology for detection of genetic predisposition to developing myocardial infarction (MI). A combination of two pathogenetically MI-related polymorphisms representing single nucleotide substitutes C1019T in connexin-37 (Cx37) gene and G894T in endothelial NO-CHHTa3bi.(eNOS) gene are examined. A high degree of risk of developing MI in an individual being examined is stated by a combination of homozygous genotype TT in C1019T polymorphism of Cx37 gene and homozygous genotype GG in G894T polymorphism of eNOS gene.

EFFECT: invention enables specifying a group of high risk of developing MI among almost healthy persons for the purpose of taking primary prevention actions.

2 dwg, 7 tbl, 4 ex

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RU 2 469 096 C2

Authors

Andreenko Elena Jur'Evna

Balatskij Aleksandr Vladimirovich

Bojtsov Sergej Anatol'Evich

Samokhodskaja Larisa Mikhajlovna

Tkachuk Vsevolod Arsen'Evich

Dates

2012-12-10—Published

2011-02-28—Filed