METHOD OF OBTAINING 5-AMINOSUBSTITUTED 1-(1-ADAMANTYL)-3,4-DINITRO-1H-PYRAZOLES Russian patent published in 2014 - IPC C07D231/38 C07D231/16 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining 5-aminosubstituted 1-(1-adamantyl)-3,4-dinitro-1H-pyrazoles, represented by general formula (1) where R₁ and R₂ independently represent H, a C₁-C₆ alkyl group with a branched or non-branched chain, adamantylmethyl group, benzyl group, which can have in a phenol ring from 1 to 3 substituents, selected from a halogen or C₁-C₆ alkyl, or R₁ and R₂ together with the nitrogen atom, which they are bound to, form a 5-8-membered heterocycle, which can additionally contain one more heteroatom, selected from N and O, and the said heterocycle can be additionally substituted with C₁-C₆ alkyl, C₁-C₆ alkoxycarbonyl and phenylcarbonyl groups. The claimed method consists in the nucleophilic substitution of a nitrogroup in 1-(1-adamantyl)-3,4,5-trinitropyrazole with respective amines of formula HNR₁R₂ in the presence of a base.

EFFECT: technological method of obtaining novel compounds, which are obtained with a sufficiently high output, is developed; obtained pyrazoles potentially are the initial compounds for the synthesis of therapeutically active compounds.

6 ex