DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR PRIMARY PLACENTAL INSUFFICIENCY Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to pathologic anatomy, and enables providing the morphological differential diagnosis of trophoblastic, endometrial and mixed forms of primary placental insufficiency in spontaneous miscarriage in the first trimester. The technique consists in performing an immunohistological analysis of the villous chorion and decidual cells of the gravidary endometrium to evaluate a vascular endothelial expression index (VEEI) and the transforming growth factor (TGF-β2). If the VEEI villous chorion expression index is 1.5 standard units or less, while the TGF-β2 expression index is 1.4 standard units or less, the trophoblastic form of primary placental insufficiency is diagnosed. If the VEEI decidual cell expression index is 1.6 standard units or less, while TGF-β2 is 2.7 standard units or more, the endometrial form of primary placental insufficiency is diagnosed; if observing the above values simultaneously, the mixed form of primary placental insufficiency is diagnosed.

EFFECT: presented method is high-informative, increases the quality of a pathology report, promotes an individual approach to the further diagnosing, treatment and rehabilitation of the female reproductive health depending on the pathogenetic form of placental insufficiency.

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