FIELD: medicine.
SUBSTANCE: invention refers to medicine, specifically to oncology, and concerns a method for the prediction of a risk of squamous metaplasia in the respiratory bronchial epithelium with detected isolated basal cell hyperplasia. The ssubstance of the method: positive nuclear expression of the Ki67 proliferation marker and membrane differentiation expression of CD 138 squamous epitheliocytes in the bronchial epithelium are measured. If the expression level Ki67≥25%, and CD138 is ≤3.5%, the risk of metaplasia in the respiratory bronchial epithelium is predicted.
EFFECT: method possesses the high information value and enables early grouping of the patients suffering from the high risk of squamous cell lung cancer and optimisation of the therapeutic approach to these patients.
2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF ONSET OF HEMATOGENOUS METASTASES ACCOMPANYING SQUAMOUS CELL LUNG CANCER | 2012 |
|
RU2489718C1 |
| METHOD FOR PREDICTION OF RECURRENT NON-SMALL-CELL LUNG CANCER | 2012 |
|
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| METHOD FOR PREDICTING CLINICAL COURSE OF DYSPLASIA PROCESS IN RESPIRATORY EPITHELIUM | 2005 |
|
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| METHOD OF DETERMINING THE RISK OF MALIGNANT TRANSFORMATION OF EPITHELIAL CELLS OF THE LARYNX IN PATIENTS WITH PRECANCEROUS DISEASES OF THE LARYNX | 2022 |
|
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| METHOD OF DIAGNOSING DEGREE OF DYSPLASIA IN BARRETT'S ESOPHAGUS | 2020 |
|
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| METHOD OF PREDICTING HEMATOGENOUS METASTASES IN INTESTINAL TYPE OF STOMACH CANCER | 2011 |
|
RU2470308C1 |
| DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR CERVICAL DYSPLASIA AND CERVICAL CANCER | 2012 |
|
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| METHOD FOR SCREENING DIFFERENTIAL DIAGNOSIS OF PRECANCEROUS DISEASES AND CANCER OF THE ORAL MUCOSA (OM) | 2021 |
|
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| METHOD FOR ASSESSING THE RISK OF DEVELOPING LUNG CANCER AGAINST THE BACKGROUND OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2022 |
|
RU2790302C1 |
| METHOD FOR PREDICTION OF RISK OF RECURRENT DISEASE OF SQUAMOUS CELL LUNG CANCER OF STAGE IIB-IIIA IN PATIENTS RECEIVING ADJUVANT POLYCHEMOTHERAPY AFTER RADICAL SURGERY | 2023 |
|
RU2815575C1 |
