FIELD: chemistry.
SUBSTANCE: invention relates to method of obtaining adhesive composition without application of solvent, to adhesive composition, which does not contain fillers and is obtained by said method. Method includes a) supply of highly-molecular polyisobutylene (HM PIB) into extruding device, where said HM PIB in fact does not contain fillers, solvents and plasticisers; b) mixing said HM PIB with low-molecular polyisobutylene (LM PIB) in said extruding device to form melt, which in fact does not contain filler, solvents and plasticisers; c) addition of active pharmaceutical ingredient (API) to said melt to obtain API/PIB melt; and d) passing said API/PIB melt through head to form said adhesive composition, which in fact does not contain fillers, solvents and plasticisers.
EFFECT: method of obtaining adhesive composition for production of pressure-sensitive adhesive matrix layers for transdermal delivery of medicinal media without application of inflammable solvents eliminates need in drying blocks, favourably influences environment without any release of solvent, with no undesirable remains of solvent remaining in obtained composition.
21 cl, 4 dwg, 1 ex
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