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2 546 034

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(51)

IPC

A61K31/4184(2006-01-01)

A61K33/18(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2013155850/15, 2013-12-16

(24)

Start date

2013-12-16

(22)

Actual filing date

2013-12-16

(45)

Published

2015-04-10

(72)

Inventor

Kit Oleg IvanovichFrantsijants Elena MikhajlovnaKaplieva Irina ViktorovnaTrepitaki Lidija KonstantinovnaStradomskij Boris Vital'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauchno-Issledovatel'Skij Onkologicheskij Institut" Ministerstva Zdravookhranenija Rossijskoj Federatsii

METHOD FOR PREVENTION OF PULMONARY METASTATIC LESIONS EXPERIMENTALLY Russian patent published in 2015 - IPC A61K31/4184 A61K33/18 A61P35/00

Abstract RU 2546034 C1

FIELD: medicine.

SUBSTANCE: pulmonary metastatic lesion in rats is simulated, and the Stellanin alcohol solution is administered intragastrically. After sarcoma 45 cells are introduced in the rats, Stellanin is applied according to a prevention schedule in a single dose of 0.4 mg/kg dissolved in water 0.5 ml, interruptedly - 5 days daily with a pause of 2 days. The length of exposure is 8 weeks. The absence of metastases is stated in 83.5% in animals of both genders in average.

EFFECT: invention enables limiting the development of pulmonary metastases.

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RU 2 546 034 C1

Authors

Kit Oleg Ivanovich

Frantsijants Elena Mikhajlovna

Kaplieva Irina Viktorovna

Trepitaki Lidija Konstantinovna

Stradomskij Boris Vital'Evich

Dates

2015-04-10—Published

2013-12-16—Filed