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2 779 358

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IPC

G09B23/28(2006-01-01)

(21) (22)

Application

2021137771, 2021-12-20

(24)

Start date

2021-12-20

(22)

Actual filing date

2021-12-20

(45)

Published

2022-09-06

(72)

Inventor

Frantsiiants Elena MikhailovnaBandovkina Valeriia AkhtiamovnaKaplieva Irina ViktorovnaShikhliarova Alla IvanovnaNeskubina Irina ValerevnaSurikova Ekaterina IgorevnaPogorelova Iuliia AleksandrovnaTrepitaki Lidiia KonstantinovnaArakelova Alina IurevnaSalatova Aina Mairbekovna

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Onkologii» Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

METHOD FOR CREATING AN EXPERIMENTAL MODEL OF TUMOR GROWTH IN CONDITIONS OF HYPOTHYROIDISM Russian patent published in 2022 - IPC G09B23/28

Abstract RU 2779358 C1

FIELD: medicine.

SUBSTANCE: invention relates to oncology, namely experimental oncology, and can be used to study in an experiment the effect of hypothyroidism on the growth of malignant tumors of various histological structures in animals of both sexes. Non-linear white rats of both sexes reproduce hypothyroidism by administering the drug Mercazolil per os at a daily dosage of 2.5 mg/100 g of weight and a total dosage of 75 mg/100 g of weight. Then, after confirming the state of hypothyroidism, a tumor suspension is injected subcutaneously under the shoulder blade: Guerin’s carcinoma or Sarcoma-45 in a dose of 2 million cells in 0.5 ml of saline solution.

EFFECT: invention provides for the creation of an experimental model of tumor growth against the background of hypothyroidism in rats of both sexes to study the effect of hypothyroidism on the development of malignant tumors of various histological structures in animals of both sexes.

1 cl, 5 tbl

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RU 2 779 358 C1

Authors

Frantsiiants Elena Mikhailovna

Bandovkina Valeriia Akhtiamovna

Kaplieva Irina Viktorovna

Shikhliarova Alla Ivanovna

Neskubina Irina Valerevna

Surikova Ekaterina Igorevna

Pogorelova Iuliia Aleksandrovna

Trepitaki Lidiia Konstantinovna

Arakelova Alina Iurevna

Salatova Aina Mairbekovna

Dates

2022-09-06—Published

2021-12-20—Filed