METHOD FOR PREDICTING METASTASES IN PATIENTS WITH SKIN MELANOMA Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to medical diagnostics in oncology, and describes a method for predicting metastases in the patients with skin melanoma. The method involves measuring VEGF C and VEGF A markers in the tumour tissue removed intraoperatively, calculating their relation; if the relation increases 5 times as much in relation to the values in intact skin derived intraoperatively from non-oncologic patients, lymphatic metastases are predicted, whereas decreasing this value 10 times as much enables predicting haematogenous metastases. The invention can be used in routine clinical practice of health care institutions, research and development establishments and oncologic dispensaries.

EFFECT: method is characterised by accessibility, relative simplicity and usability of assessing the vascular growth factors and enables predicting the risk of latent metastatic phase of the disease, conducting the objective control of the malignant process, particularly skin melanoma, predicting metastases before the clinical manifestations and including the patients into the risk group for intensive follow-up, taking the timely measures for prescribing the adjuvant treatment.

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