METHOD OF POSTNATAL DIAGNOSTICS OF FOETAL ALCOHOL SYNDROME IN DECEASED YOUNG CHILDREN Russian patent published in 2015 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: method of the postnatal diagnostics of foetal alcohol syndrome in deceased young children consists in the following: the brain of the deceased child is weighed and its weight is fixed. Morphological changes in the brain are identified. For this purpose blocks of the brain substance are cut out from the convexital cortex of the sensomotor zone, hypothalamic zone and cerebellum. Analysis by light-optical microscopy with the preliminary staining of the brain cuts is carried out. The staining is performed with hematoxylin-eosin by Van Gieson and by Nissl. Results of the analysis are used to diagnose foetal alcohol syndrome in case if a complex of the following morphological changes of the brain is present: in the brain substance from the convexital cortex of the sensormotor zone there are sections of rarefaction in middle layers, chromatolysis of the cytoplasm of the nerve cells and pyknotic changes, in the brain substance of the hypothalamic area there is chromatolysis of the nerve cells in the form of the Nissl substance margination, pericellular oedema, in the brain substance of the cerebellum there is the rarefaction of cells, dystrophic changes of the Purkinje cells, with the fixed weight of the brain being lower than the minimally admissible for a normally developed child of the similar age.

EFFECT: increase of reliability and extension of the arsenal of means of forensic examination for the postnatal diagnostics of foetal alcohol syndrome in deceased young children.

3 dwg, 1 ex