METHOD FOR ASSESSING FUNCTIONAL STATE OF HAEMOSTASIS SYSTEM Russian patent published in 2015 - IPC G01N33/86 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haemocoagulogy, and can be used for detecting a group of individuals suffering a risk of haemocoagulation complications. Substance of the method: measuring initial blood coagulation trace amplitude, determining initial and final blood coagulation parameters and comparing them to corresponding normal blood coagulation parameters; if observing oppositely directed deviations, the disturbed functional state of the haemostasis system is diagnosed. A time constant is determined according to a calibration curve; the calibration procedure a priori covers two measured U₁, U₂ and known U₀₁, U₀₂ values of lower t₁ and upper t₂=kt₁ limits of the adaptive range; the calibration curve U_0i is a blood limit strength function compensating an uncertainty T* of the random time constant T₀ and relating the reference U_ri and measured U_i characteristics by normalising the measured values by the known ones the calibration curve U_0i shows the actual values of the time constant T₀ and blood limit strengthU₀ which are used to draw the calibration curve of the blood limit strength, reference performance U_ri

and to determine initial T_i and final T_f blood coagulation parameters wherein U_i, U_f are the normalised initial and final blood coagulation thresholds.

EFFECT: invention enables reducing a procedure error by tens orders, increasing a coagulation time accuracy by 4 orders, and reducing the efficiency three times as much that eventually provides higher metrological effectiveness of computer analysers applicable for the purpose of automating the process of detecting the individuals having a risk of haemocoagulation complications.

4 dwg