METHOD OF DETERMINING FUNCTIONAL STATE OF THE HEMOSTASIS SYSTEM Russian patent published in 2018 - IPC G01N33/86 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and can be used to determine the functional state of the hemostasis system. To do this, measure the recording amplitude of the clotting process at the beginning of the process. Determine the indices of the beginning and the end of the coagulation process of the electrocoagulogram of the blood. They are compared with the same indices of the process of blood coagulation in norm and with differently directed deviations. And they diagnose a violation of the functional state of the hemostasis system. In this case, the time constant and the limiting voltage according to the calibration characteristics are determined. Calibration is carried out a priori for two measured U₁, U₂ and the known U₀₁, U₀₂ values of the bottom t₁ and the upper t₂=kt₁ boundaries of the adaptive range. Calibration characteristics are the function of the limiting blood pressure U_0i, which compensates for the uncertainty of T_0i time constant T₀, and the time constant function T_0i, and also compensating uncertainty U_0i of the limiting voltage U₀, connecting the reference U_ei and the measured U_i characteristics due to the normalization of the measured values known by the calibration characteristics U_0i, T_0i. Find the real values of the time constant T₀ and the limiting voltage U₀ blood, on which the calibration characteristic of the limiting voltage U_0i blood, the calibration characteristic of the time constant T_0i, the reference characteristic U_ei. Determine the start of T_n and end T_k the process of blood clotting.

EFFECT: invention allows to increase by 2 orders of magnitude the accuracy of measuring blood clotting time and to increase the effectiveness of identifying individuals from the risk group for hemocoagulation complications.

1 cl, 4 dwg