METHOD OF EVALUATING IMPAIRMENT OF HAEMOGLOBIN OXYGENATION IN ERYTHROCYTES OF PERIPHERAL BLOOD OF PREGNANT WOMEN IN THIRD TRIMESTER OF GESTATION WITH REDUCTION OF GLUCONEOGENESIS AT BACKGROUND OF CYTOMEGALOVIRAL INFECTION AGGRAVATION Russian patent published in 2015 - IPC G01N33/48 

Abstract RU 2549432 C2

FIELD: medicine.

SUBSTANCE: invention deals with a method of evaluating a threat of hypoxia formation in pregnant women with the aggravation of the cytomegaloviral infection in the third trimester of gestation. The essence of the method: in peripheral blood a titre of antibodies to cytomegalovirus is determined, the activity of phosphoenolpyruvate dehydrogenase is determined by the histochemical method, the content of discocytes, echinocytes, target-shaped erythrocytes, degenerative forms of erythrocytes, oxyhaemoglobine quantity are determined in peripheral blood. If the titre of antibodies to cytomegalovirus is 1:1600, detection of the reduction of phosphoenolpyruvate dehydrogenase activity to 12.0±0.09 c. u.: reduction of discocytes in peripheral blood to 74.0±1.3%, increase of the number of echinocytes to 7.0-0.2, target-shaped erythrocytes to 8.5±0.3%, degenerative forms of erythrocytes to 10.5±0.15% and reduction of the oxyhaemoglobine quantity to 92.0±1.6% a threat of formation of haemic hypoxia is evaluated.

EFFECT: improvement of the method of the threat evaluation.

2 dwg

Similar patents RU2549432C2

Title Year Author Number
METHOD FOR ASSESSING DISTURBED HAEMOGLOBIN OXYGENATION WITH REDUCED MICROVISCOSITY OF PERIPHERAL ERYTHROCYTE MEMBRANE OF PREGNANT WOMEN IN THIRD TRIMESTER OF GESTATION AND AGGRAVATED CYTOMEGALOVIRUS INFECTION 2013
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
  • Ishutina Natal'Ja Aleksandrovna
  • Kutepova Ol'Ga Leonidovna
RU2540425C1
METHOD FOR ASSESSING ERYTHROCYTE MEMBRANE STABILITY IN AGGRAVATED CYTOMEGALOVIRAL INFECTION BY HISTOCHEMICAL MEASUREMENT OF CALCIUM ION CONTENT IN PREGNANT WOMEN'S PERIPHERAL BLOOD ERYTHROCYTES 2014
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
RU2563827C1
METHOD FOR ASSESSING DISTURBED HAEMOGLOBIN OXYGENATION IN PERIPHERAL BLOOD ERYTHROCYTES OF PREGNANT WOMEN ON THEIR THIRD TRIMESTER OF PREGNANCY SUFFERING AGGRAVATED CYTOMEGALOVIRAL INFECTION 2013
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
  • Dovzhikova Inna Viktorovna
  • Kutepova Ol'Ga Leonidovna
RU2535055C1
METHOD FOR ASSESSING INHIBITORY ACTION OF CYTOMEGALOVIRAL INFECTION ON CARBONIC ANHYDRATE ACTIVITY IN PREGNANT WOMAN'S PERIPHERAL RED CELLS 2013
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
RU2537180C1
EVALUATION OF METHOD OF INHIBITING ACTIVITY OF ADENYLATE CYCLASE IN ERYTHROCYTE MEMBRANES IN AGGRAVATED CYTOMEGALOVIRUS INFECTION IN PREGNANT WOMEN IN THIRD TRIMESTER OF GESTATION 2015
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatolevna
  • Dovzhikova Inna Viktorovna
RU2577300C1
METHOD FOR ASSESSING INDUCING ACTION OF CYTOMEGALOVIRUS INFECTION ON HEMOGLOBIN OXYGENATION IN THIRD TRIMESTER OF GESTATION WITH UNDERLYING HEMOGLOBIN AND 2,3-BISPHOSPHOGLYCERATE MEASUREMENT IN PERIPHERAL RED BLOOD CELLS 2012
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
  • Kutepova Ol'Ga Leonidovna
RU2504775C1
METHOD FOR DETERMINATION OF THREAT OF HEMIC ANEMIA FORMATION DURING PREGNANCY IN THIRD TRIMESTER OF GESTATION IN CASE OF CYTOMEGALOVIRUS INFECTION EXACERBATION, INHIBITING ACTIVITY OF SH-GROUPS IN RED BLOOD CELLS AND LEADING TO DECREASED HEMOGLOBIN OXYGENATION 2015
RU2612010C1
METHOD FOR DETERMINING STABILITY OF MEMBRANES OF PERIPHERAL BLOOD ERYTHROCYTES IN CASE OF REDUCTION OF BAND-4,1 PROTEIN AT BACKGROUND OF EXACERBATION OF CYTOMEGALOVIRAL INFECTION IN THIRD GESTATION TRIMESTER 2015
  • Lutsenko Mikhail Timofeevich
  • Andrievskaya I.A.
  • Mironenko Artem Gennadevich
RU2611360C1
METHOD FOR ASSESSING EFFECT OF CYTOMEGALOVIRAL INFECTION ON ERYTHOROCYTE MEMBRANE STABILITY OF NEWBORNS OF MOTHERS SUFFERED AGRAVATED CYTOMEGALOVIRAL INFECTION IN THIRD TRIMESTER OF PREGNANCY 2014
  • Lutsenko Mikhail Timofeevich
  • Andrievskaja Irina Anatol'Evna
  • Kutepova Ol'Ga Leonidovna
  • Babenko Ol'Ga Petrovna
  • Mironenko Artem Gennadievich
RU2546009C1
METHOD FOR OXYHEMOGLOBIN REDUCTION ASSESSMENT IN CASE OF INDUCING EFFECT OF CMV INFECTION ON RED BLOOD CELLS HEMOGLOBIN STRUCTURE, LEADING TO HEINZ'S BODIES FORMATION 2015
  • Lutsenko Mikhail Timofeevich
  • Andrievskaya Irina Anatolevna
RU2617534C1

RU 2 549 432 C2

Authors

Lutsenko Mikhail Timofeevich

Andrievskaja Irina Anatol'Evna

Dovzhikova Inna Viktorovna

Kutepova Ol'Ga Leonidovna

Dates

2015-04-27Published

2013-08-09Filed