FIELD: chemistry.
SUBSTANCE: enzyme is coated with an internal envelope of a polycation and an external envelope of a polyanion, where the polycation used is protamine or polyarginine, the polyanion used is a block-copolymer of poly(glutamic acid) and polyethylene glycol, wherein the nanoparticle has a hydrodynamic diameter in the range of 40-70 nm. The invention also relates to a dispersion which contains nanoparticles of the antioxidant enzyme superoxide dismutase for medical use in the form of polyelectrolyte complexes of the type enzyme/polycation/polyanion, and a method of producing said dispersion.
EFFECT: high stability of the enzyme in a foreign medium with preservation of the activity of the enzyme.
9 cl, 1 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMER NANOPARTICLES OF ENZYME-POLYCATION-POLYANION COMPOSITION CONTAINING ANTIOXIDANT ENZYME FOR APPLICATION IN MEDICINE AND METHOD FOR OBTAINING THEREOF | 2013 |
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RU2575836C2 |
| METHOD OF PRODUCING A WATER-CONTAINING SUSPENSION OF PARTICLES CONSISTING OF AN ANTIOXIDANT ENZYME SUPEROXIDE DISMUTASE, A POLYCATION AND A POLYANION | 2019 |
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| METHOD OF PRODUCING PARTICLES FOR TREATING GYNECOLOGICAL AND PROCTOLOGIC DISEASES ACCOMPANIED BY OXIDATIVE STRESS | 2019 |
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| COMPOSITION FOR TREATING GYNAECOLOGICAL AND PROCTOLOGIC DISEASES ACCOMPANIED BY OXIDATIVE STRESS | 2019 |
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| PHARMACEUTICAL COMPOSITION FOR TREATING EYE DISEASES ACCOMPANIED BY OXIDATIVE STRESS, AND A METHOD FOR USE THEREOF | 2018 |
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| ENZYMIC BIOCATALYST WITH ANTIOXIDANT ACTIVITY FOR DETOXIFICATION OF PHOSPHORORHANGE COMPOUNDS | 2017 |
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RU2648169C1 |
| METHOD OF PRODUCING MICROENCAPSULATED FORM OF THERAPEUTIC PROTEIN SUPEROXIDE DISMUTASE FOR ORAL APPLICATION | 2015 |
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RU2583923C1 |
| ASPARTYL DERIVATIVES OF HISTAMINE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND THEIR USING AS MODULATORS OF ENZYME ACTIVITY OF ANTIOXIDANT PROTECTION | 2005 |
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RU2287524C1 |
| DIAGNOSTIC TECHNIQUE FOR METABOILIC DISORDERS IN BODY IN OXIDATIVE STRESS ENVIRONMENT | 2010 |
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RU2436101C1 |
