SUBSTITUTED CYCLOHEXYLDIAMINES Russian patent published in 2014 - IPC C07D209/20 C07D403/06 C07D413/06 C07D417/06 A61K31/405 A61K31/422 A61K31/4245 A61K31/427 A61K31/41 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (1), in which Y₁, Y₁', Y₂, Y₂', Y₃, Y₃', Y₄ and Y₄' denote -H; R₁ and R₂ denote an unsubstituted -C_1-8-aliphatic; R₃ denotes an unsubstituted -C_6-16-aryl; R₄ denotes -H or -C(=O)R₀, where R₀ denotes -C_1-8-aliphatic, unsubstituted or mono- or polysubstituted with substitutes independently selected from a group consisting of -F, -Cl, -Br, -I and -CN; Q denotes unsubstituted -C_1-8-aliphatic-heteroaryl; X denotes =O, =CR₆R₇ or =N-R₆, wherein R₅ denotes -NH₂, -NH-(unsubstituted-C_1-8-aliphatic) or -N-(unsubstituted-C_1-8-aliphatic)₂, if X denotes =O, or R₅ and R₆ together form a 5-member ring in which the remaining ring atoms independently denote C, N, S or O, wherein the 5-member ring denotes 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, oxazolyl or thiazolyl, in each case unsubstituted or monosubstituted with unsubstituted C₁-C₈aliphatic or =O, or unsubstituted tetrazolyl, if X denotes =N-R₆, or R₅ and R₆ together form unsubstituted phenyl, and R₇ denotes -H, if X denotes =CR₆R₇, where "aliphatic" in each case represents a branched or straight, saturated hydrocarbon residue; "aryl" in each case independently denotes a carboxylic ring system containing at least one aromatic ring which does not contain heteroatoms, where the aryl may be optionally condensed with other saturated, (partially) unsaturated or aromatic ring systems; "heteroaryl" denotes indolyl; in the form of a separate stereoisomer or a mixture thereof, in the form of free compounds and/or physiologically compatible salts thereof. The compound of formula

is used to obtain a medicinal agent having affinity for the µ-opioid receptor and the ORL1-receptor, and for treating pain.

EFFECT: substituted cyclohexyldiamines, having affinity for the µ-opioid receptor and the ORL1-receptor.

7 cl, 1 tbl, 29 ex