FIELD: chemistry.
SUBSTANCE: present invention relates to biotechnology and is a genetically modified strain of Streptomyces thermotolarences WSJ-IA, which produces isovaleryl spiramycin I. The present invention also discloses a method of producing said strain. The method includes steps of constructing a recombinant plasmid comprising a double gene ist-acyB2 and transforming the plasmid into the isovaleryl spiramycin I - producing strain WSJ-IA. The invention also discloses a method of producing isovaleryl spiramycin I by culturing the Streptomyces thermotolarences WSJ-IA strain in a culture medium.
EFFECT: present invention increases the output of the obtained isovaleryl spiramycin I.
3 cl, 3 dwg, 5 tbl, 4 ex
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