METHOD OF PREDICTING FORMATION OF OCCLUSIVE POST-HAEMORRHAGIC HYDROCEPHALUS IN PREMATURE BABIES WITH EXTREMELY LOW BODY WEIGHT AT BIRTH Russian patent published in 2015 - IPC G01N33/535 

FIELD: medicine.

SUBSTANCE: in a premature baby the concentration of neuron-specific enolase (NSE), concentration of a brain-derived neurotrophic factor (BDNF), concentration of a vascular-endothelial growth factor (VEGF) in umbilical blood and concentration of the vascular-endothelial growth factor (VEGF) in peripheral blood are determined on the basis of the enzyme immunoassay of umbilical and peripheral blood serum on the 7-th day of life, a prognostic index (PI) is calculated by formula: PI=-0.007×X₁+0.006×X₂-0.05×X₃+0.0004×X₄-3.9, where X₁ is VEGF content in umbilical blood at birth (ng/ml); X₂ is VEGF content in peripheral blood on the 7-th day of life (ng/ml); X₃ is NSE content in umbilical blood (mcg/l); X₄ is BDNF content in umbilical blood (ng/ml); Const=-3.9. When PI is higher than 0, a conclusion about the absence of risk of occlusive posthaemorrhagic hydrocephalus formation is made, and if PI is lower than 0, a high risk of the said pathology development is predicted.

EFFECT: invention makes it possible to increase the efficiency of prediction of occlusive posthaemorrhagic hydrocephalus formation in the premature children with an extremely low body weight at birth.

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