METHOD FOR PREDICTION OF RISK OF SEVERE NEONATAL NERVOUS SYSTEM INVOLVEMENT IN NEW-BORNS OF VARIOUS GESTATIONS Russian patent published in 2014 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neonatology and child neurology, and can be used to predict a risk of a neonatal central nervous system (CNS) involvement in new-borns of various gestations. Substance of the method: vascular endothelial growth factor and blood serum neurospecific enolase are measured. That is followed by calculating a probability of the severe central nervous system involvement p by formula: p=1/(1+e^-F), wherein e is a base of natural logarithm = 2.718; F is a discriminant function calculated by formula: F=0.0235·VEGF-4.5·NSE-2.46, wherein VEGF is the blood serum vascular endothelial growth factor; NSE is the blood serum neurospecific enolase. If p is 0.5 or more, a low risk is predicted, and if p is less than 0.5, a high risk of the severe CNS involvement is predicted.

EFFECT: method provides high sensitivity, diagnostic accuracy and information value of the method that provides wider application, particularly for new-borns of various gestations.

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