METHOD FOR PREDICTION OF INFANTILE CEREBRAL PARALYSIS IN PREMATURE NEWBORNS WITH EXTREMELY LOW BIRTH WEIGHT Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: substance of the method consists in determining the concentrations of neuron-specific enolase (NSE) and vascular endothelial growth factor (VEGF) in umbilical blood serum and peripheral blood serum, the concentrations of brain-derived neurotrophic factor (BDNF) in peripheral blood serum on the 7^th day of birth; that is followed by calculating a prognostic index (PI) by formula: PI=0.033×X1+0.016×X2-0.36×X3+0.002×X4+0.00054×X5-4.0, wherein X1 is the NSE concentration in umbilical blood (mcg/l); X2 is the VEGF concentration in umbilical blood (ng/ml); X3 is the NSE concentration in peripheral blood on the 7^th day of life (mcg/l); X4 is the VEGF concentration in peripheral blood on the 7^th day of life (ng/ml); X5 is the BDNF concentration in peripheral blood on the 7^th day of life (ng/ml); Const=-4.0. If PI is less than 0, a low risk of ICP is stated. If PI is more than 0, a high risk of the given pathology is predicted.

EFFECT: method enables increasing the effectiveness of predicting infantile cerebral paralysis in the premature newborns with extremely low birth weight.

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