METHOD OF OBTAINING NANOCRYSTALLINE SILICATE-SUBSTITUTED CARBONATEHYDROXYAPATITE Russian patent published in 2015 - IPC A61L27/12 A61L27/32 C01B25/32 B82B3/00 

FIELD: medicine.

SUBSTANCE: invention relates to method of obtaining nanocrystalline silicate-substituted carbonatehydroxyapatite (CHA), which includes mixing solutions of salts of calcium, phosphate and silicate, settling, filtering, washing from mother liquor and drying, solutions of calcium nitrate tetrahydrate, anhydrous disubstituted ammonium phosphate, sodium methasilicate pentahydrate are mixed with ratio of concentrations Ca/(P+Si) equal 1.70, and part of silicate-ions in the total quantity of sediment-forming anions $$(X_{Si{O}_4^{4-}}=C_{Si{O}_4^{4-}}/(C_{P{O}_4^{4-}}+C_{Si{O}_4^{4-}})),$$ constituting not more than 30 mol. %, pH is supported at level 9.00-12.00, obtained as a result of precipitation solid phase is kept under mother liquor for 2 days at temperature 22-25°C, then filtered out, washed with distillated water and dried at 80°C to constant weight. CHA considering created structure defectiveness of is characterised by higher solubility in physiological solution, and thereupon can be applied for formation of calcium-phosphate coatings on metal implants, as well as for creation of novel ceramic and composite materials for traumatology, orthopaedics and maxillofacial surgery.

EFFECT: increase of compound solubility.

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