SUTURE MATERIAL WITH ANTITHROMBOTIC COATING Russian patent published in 2015 - IPC A61L17/10 A61L33/10 A61L33/06 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and represents a suture material with an antithrombotic coating consisting of a polypropylene carrier suture coated with 3-hydroxybutyrate/3-hydroxyvalerate (PHBV) copolymer in the concentration of 1-6%, and at least one antithrombotic substance; the suture material coating is fixed by a chemical reaction: at the first stage, the carrier suture is immersed into a biopolymer for 10 minutes and dried at room temperature for 3 hours in a dust-free chamber, and then for 1 hour in mixed air and ozone; the suture is kept for 5 hours in the methacryloyl chloride vapour at a temperature of 85-90°C; the second stage involves the suture modification with heparin (1,000 units/ml); the suture is immersed into heparin at a temperature of 2-5°C for 10 hours and for 14 hours into heparin at room temperature; the suture material is finally dried in the dust-free chamber at room temperature until completely dry.

EFFECT: invention provides higher hemo- and biocompatibility of the retention suture material, as well as higher antithrombotic characteristics by the multilayer modification of the retention suture by the biodegradable polymer and heparin.

3 cl, 1 tbl, 3 dwg